Wellbutrin for ADHD: Is it as effective as stimulant-based treatments?

Does Using Wellbutrin for ADHD Work?

Yes, Wellbutrin can be effective for ADHD, particularly in adults. However, because research is ongoing, Wellbutrin remains an off-label treatment for ADHD and is not FDA-approved for this use.

Here’s how Wellbutrin works for ADHD: Unlike many antidepressants, Wellbutrin has stimulating effects and does not affect serotonin levels. It functions as a norepinephrine and dopamine reuptake inhibitor (NDRI), meaning it increases the availability of these neurotransmitters—norepinephrine and dopamine—by preventing their reabsorption in the brain. This can help improve focus and concentration. 

How Effective is Wellbutrin for ADHD?

Though research on Wellbutrin’s effectiveness for ADHD is still underway, the findings are promising. Studies indicate that Wellbutrin is linked to a noticeable reduction in ADHD symptoms. One study found that participants who took Wellbutrin better managed their ADHD symptoms as compared to those who were given a placebo. Some research even suggests that, for certain individuals, Wellbutrin may be as effective as stimulant medications. Given these findings, many clinicians continue to prescribe Wellbutrin to manage ADHD if other stimulants are not working for their patients. 

Can Wellbutrin Help with Focus?

Difficulty initiating, sustaining, and transitioning focus and attention are common symptoms of ADHD. Wellbutrin for ADHD can help some individuals focus better at work, school, in relationships, and at home. 

How Fast Does Wellbutrin Work for ADHD?

Wellbutrin can start to provide benefits for those with ADHD within 2-4 weeks of beginning a regimen. Some people might notice effects more quickly, perhaps within 3-7 days. 

When taking Wellbutrin for ADHD, this prescription is available as a tablet that you can take with or without food. Even if you’re in a rush to see increased benefits from taking Wellbutrin for ADHD, you should never take more than your prescribed dose, unless at a professional’s direction. By taking more than the prescribed amount of Wellbutrin for ADHD, you could put yourself at an increased risk of developing side effects.

Wellbutrin vs. Adderall

Even though Wellbutrin has stimulating effects, it is classified as an antidepressant and is not typically used for ADHD. Adderall, on the other hand, is classified as a stimulant and is specifically meant to treat ADHD symptoms. Other stimulant ADHD medications include Ritalin, Concerta, and Vyvanse. 

Is Wellbutrin Better than Adderall for ADHD?

Generally, Adderall is better for ADHD than Wellbutrin. Adderall is a stimulant medication that is specifically meant to target ADHD symptoms and studies have shown that it has high efficacy for improving focus, mood, and control over impulsive behavior. For this reason, Adderall, and other similar stimulant medications, are used as a first line of defense for people with ADHD. That said, Adderall isn’t effective for everyone. One study found that 30% to 50% of people with ADHD experience limited benefits from stimulants. For this reason, Wellbutrin can be a good alternative. 

Why Take Wellbutrin for ADHD?

Not everyone responds well to stimulant medications, as well as considering their high potential for misuse, Wellbutrin is sometimes an appealing alternative that may be highly effective for treating ADHD. 

Your psychiatric provider may consider using Wellbutrin to treat your ADHD if:

• You aren’t responding well to the initial medication they prescribed you
• They have limitations to prescribing stimulants or controlled substances
• You have a history of substance use that puts you at risk of misuse of a stimulant medication
• You have another condition such as depression, in addition to ADHD 

When comparing Adderall to Wellbutrin for ADHD, it’s important to remember that your results, if you see benefits, will depend on your symptoms, as well as how your body responds to either medication.

Can You Take Wellbutrin and Adderall Together for ADHD?

Yes, you may be prescribed both Wellbutrin and Adderall for ADHD if stimulants alone haven’t been effective for you or if you experience ADHD along with depression. Note that taking Wellbutrin along with Adderall can potentially increase some side effects, such as high blood pressure, sensitivity to alcohol, and anxiety. Combining these medications should always be done under close medical supervision to manage potential side effects and ensure safe, effective treatment.

Can I Use Wellbutrin for ADHD Without a Doctor’s Prescription?

No, you can’t use Wellbutrin without a prescription. The use of Wellbutrin requires a diagnosis from a psychiatric provider or medical doctor for ADHD, depression, or another mental health condition. After being diagnosed, and considering your personal treatment preferences and symptoms, a prescription to take Wellbutrin for ADHD could be provided. 

Can Wellbutrin Worsen ADHD Symptoms?

Ideally, prescribing someone Wellbutrin for ADHD is intended to help reduce the symptoms of ADHD. However, everyone does not respond the same and some people may find it not beneficial for their ADHD. 

Although Wellbutrin for ADHD may not work well as a treatment for everyone’s symptoms, it’s unlikely to make ADHD effects worse. But it may cause common side effects, which include: 

• Vertigo (dizziness)
• Poor appetite 
• Blurry or reduced vision
• Irritability
• Sleep problems
• Headaches
• Nausea
• Vomiting
• Dry mouth
• Constipation
• Muscle tremors 
• Sweating

If you are experiencing these symptoms, it’s important to talk with your psychiatric provider about whether Wellbutrin for ADHD is working effectively. There may be another medication that you respond to more positively and with fewer side effects. 

Alternatives for ADHD Treatment

If neither Wellbutrin nor Adderall is right for you, there are other medications to treat ADHD to consider. ADHD can be managed with stimulant medications, like: Vyvanse (lisdexamfetamine), Ritalin (methylphenidate), Dexedrine (dextroamphetamine), and Concerta (methylphenidate). You can also try medications that are not stimulants, like: Intuniv (guanfacine), Strattera (atomoxetine), and Kapvay (clonidine). Often when you are taking psychiatric medication, it’s important to supplement with therapy. You may also choose to try therapy, like cognitive behavioral therapy, without medication to treat ADHD.

Final Thoughts

Wellbutrin can be a good alternative to stimulant-based treatments for ADHD, particularly for those who may not respond well to stimulants or have concerns about their potential for misuse. While it’s not FDA-approved and may not work for everyone, Wellbutrin can be effective in helping some people manage their ADHD symptoms. Since different people have different experiences with ADHD treatments, it’s important to consider all available options, including other medications and therapy. Talk to a mental healthcare provider to determine the best approach for managing your ADHD.