duloxetine (Cymbalta)

Meet with a licensed provider online to explore if an antidepressant medication like duloxetine (Cymbalta) may be right for you.

Treatment for:
depression, generalized anxiety disorder, social anxiety disorder

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How prescribing works

  • 1

    Find the right provider

    Browse providers online or call us and we’ll help you find someone who accepts your insurance and fits your needs. Pick a time that works for you and choose how you’d like to pay.

  • 2

    Get started with treatment

    At your first session, share what you’re experiencing and what you’re hoping to get out of treatment. Together, you’ll discuss your options—including whether medication might be a good fit. If so, your provider can send a prescription directly to your local pharmacy.

  • 3

    Track your progress

    Your provider will check in regularly to make sure your treatment plan is working for you and adjust as needed.

What is an SNRI?

A serotonin-norepinephrine reuptake inhibitor (SNRI) is a class of medication commonly used to treat mental health conditions like anxiety, depression, OCD, and PTSD.

How does an SNRI work?

SNRIs increase the availability of serotonin and norepinephrine in the brain. Serotonin is a naturally-occurring brain chemical that supports the regulation of mood and memory; norepinephrine is also a naturally-occurring brain chemical that supports focus, attention, and energy.

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FAQs about duloxetine (Cymbalta)

What is duloxetine (Cymbalta) used to treat?

Duloxetine is used to treat depression, anxiety, pain from diabetic neuropathy, fibromyalgia and chronic musculoskeletal pain. It is a serotonin-norepinephrine reuptake inhibitor (SNRI) that works by balancing levels of serotonin and norepinephrine in the brain.

Does duloxetine (Cymbalta) cause weight gain or loss?

Weight gain or loss wasn't a commonly reported side effect of duloxetine, but it's possible. Loss of appetite is a common side effect when beginning duloxetine, so you may experience temporary weight loss. If you have questions about weight loss or weight gain with duloxetine treatment, talk with your provider.

What is the lowest dose of duloxetine (Cymbalta)?

The lowest dose of duloxetine depends on several factors. They include the condition the drug is being used to manage, your age, any other medications you may be taking and other factors. To learn more about the lowest doses of duloxetine to treat your condition, talk with your provider.

How long does it take for duloxetine (Cymbalta) to work?

How long it takes duloxetine to start working depends on various factors, including the severity of your condition. Keep in mind that it may take several weeks for duloxetine to start working—Don't stop taking the medication on your own if you feel it's not working for you. Instead, talk with your provider. They can discuss your concerns and provide more information on duloxetine's effectiveness for you.

Does duloxetine (Cymbalta) make you sleepy?

Yes—Sleepiness is one of the common side effects of duloxetine. Until you become used to the effects of the medication, don't drive or operate machinery or perform tasks that require alertness. If sleepiness is bothersome and doesn't go away, talk with your provider. They can discuss ways to manage this effect of duloxetine such as the time of day you take the medication.

Is duloxetine (Cymbalta) a controlled substance?

No. Duloxetine is not a federally controlled substance and is not known to be habit forming. However, don't suddenly stop taking duloxetine because it may cause withdrawal symptoms. These are side effects that happen when your body becomes used to a medication over time. Symptoms may include headache, dizziness, nausea, vomiting. Talk with your provider if you want to stop taking duloxetine. They'll gradually lower your dose till you can stop the medication to lower your risk of withdrawal symptoms.

What are the side effects of duloxetine (Cymbalta)?

Some common side effects of duloxetine include: dizziness, nausea, drowsiness, headache, dry mouth, excessive sweating, loss of appetite. Keep in mind these are not all the possible side effects of duloxetine. Duloxetine also has other serious side effects. Talk with your provider or pharmacist if you have specific questions about side effects of duloxetine.

Can I get a prescription online?

You can meet with a licensed provider at Thriveworks, in person or online depending on your state. If it’s clinically appropriate, they may prescribe medication for a diagnosed mental health condition. Your provider will send your prescription to a local pharmacy to be filled.

Can I use my health insurance for prescriptions and refills?

Thriveworks accepts most major insurance plans for psychiatry and therapy services. Your insurance may also cover the cost of any medication your provider prescribes, which can be filled at a local pharmacy. Check with your plan to confirm your medical and prescription coverage.

How do I get a prescription at Thriveworks?

Schedule a session with a licensed psychiatric provider at Thriveworks. After discussing your symptoms and treatment goals, your provider may recommend medication and/or additional services to help you get where you want to be.

Is Thriveworks LegitScript certified?

Yes. Thriveworks is LegitScript-certified, meaning we’ve been reviewed and verified by one of the most trusted compliance organizations in healthcare. This certification confirms that our services meet high standards for legality, safety, and transparency.

This information has been reviewed for accuracy and approved by our licensed psychiatric team. Published October 3, 2024
Dr. Scott Gordon

Accepting medication as part of your mental health care plan is an individual and often deeply personal decision. At Thriveworks, we’re here to help you understand your care options and support you on the path toward wellness. We prioritize treating the whole patient, whether through medication, therapy, or a combination of both — guided by clinical best practices and rigorously developed treatment strategies to help clients safely and efficiently resolve their symptoms.

Dr. Scott Gordon Chief Medical Officer

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