6 signs Wellbutrin is working—and what to do if it’s not by Alex Evans, PharmD | Aug 20, 2026 | Medication, Mental Health Topics If you recently started taking Wellbutrin (bupropion), you might be wondering when you’ll start feeling like yourself again. Is that flicker of energy the medication or just a good morning? Is jitteriness a bad sign, or just your body adjusting? When you’re eager to feel better, it can be tempting…