Celexa vs Zoloft: How they compare, what they treat, and how to choose by Alex Evans, PharmD | Jan 22, 2026 | Medication, Mental Health Topics You’re comparing antidepressants, and the options feel overwhelming. Celexa and Zoloft are both first-choice medications for depression, but they have different FDA approvals, side effect profiles, and drug interactions that could make one a better fit for you than the other. Here’s what you need to know to have an…